Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% Ph. Eur., USP

Supplier: VWR Chemicals
Warning

Synonyms: 2-Amino-2-(hydroxymethyl)propane-1,3-diol(tris), Tromethamine, Tris(hydroxymethyl)methylamine, 2-Amino-2-(hydroxymethyl)propane-1,3-diol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, Trizma(R) base, TRIS base, THAM

87020.290EA 14004 INR
87020.290 87020.360 87020.460
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% Ph. Eur., USP
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)

Appearance: White or almost white, crystalline powder or colourless crystals.
Residues of metal catalysts or reagents: Conforms to EMEA/CHMP/SWP/4446/2000


Caution: Not for use as Active Pharmaceutical Ingredient (API)

Formula: NH₂C(CH₂OH)₃
MW: 121,14 g/mol
Boiling Pt: 357 °C (1013 hPa)
Melting Pt: 169…172 °C
Density: 1,328 g/cm³ (20 °C)
Storage Temperature: Ambient
MDL Number: MFCD00004679
CAS Number: 77-86-1
EINECS: 201-064-4
Merck Index: 13,09842
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Specification Test Results

Appearance Conforms (see CoA/CoS)
Heavy metals (as Pb) Max. 10 ppm
Residual solvents Class 2 (ICH Q3C) : Passes test USP
Methanol Below option 1 limit
Other residual solvents(Ph.Eur./ICH) Unlikely by manuf.process
Residues of metal catalysts or reagents Unlikely by manuf.process
As (Arsenic) Max. 2 ppm
Cd (Cadmium) Max. 1 ppm
Co (Cobalt) Max. 1 ppm
Hg (Mercury) Max. 2 ppm
Ni (Nickel) Max. 50 ppm
Pb (Lead) Max. 3 ppm
V (Vanadium) Max. 2 ppm
Conforms to Ph.Eur./USP Passes test
Ph.Eur. specifications: Max. 0.1 %
Assay (calculated on dried) [Ph.Eur.] 99.0 --> 100.5 %
Identification B [Ph.Eur.] 168 --> 174 °C
Identification C Passes test USP
Appearance of solution Passes test Ph.Eur.
pH (20°C; 5 %) [Ph.Eur.] 10.0 --> 11.5
Related substances [Ph.Eur.] Max. 1.0 %
Cl (Chloride) [Ph.Eur.] Max. 100 ppm
Fe (Iron) [Ph.Eur.] Max. 10 ppm
Loss on drying (105°C) [Ph.Eur.] Max. 0.5 %
Sulphated ash [Ph.Eur.] Max. 0.1 %
USP specifications:
Assay (calculated on dried basis) [USP] 99.0 --> 101.0 %
Identification A Passes test USP
Identification B Passes test USP
Residue on ignition [USP] Max. 0.1 %
Melting range or temperature [USP] 168 --> 172 °C
pH (5 %) [USP] 10.0 --> 11.5
Loss on drying (105°C; 3 h) [USP] Max. 1.0 %

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