Buffer management solutions
Buffers play a significant role in biopharmaceutical manufacturing. Typically representing a major component by volume used in downstream processing steps, buffer preparation constitutes a significant proportion of a facility‘s footprint, labor requirements and equipment cost.
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There are multiple ways buffers can be supplied; an established way to manufacture buffers in-house is with the use of USP or WFI grade water to hydrate powders in stainless steel or single-use tanks.
While this method is established and ideal for large volumes, these operations need significant infrastructure. This includes warehouse space for holding raw materials prior to use and a weighing and dispensing area for raw materials.
Therefore, looking at the cost and complexity of in-house buffer preparation, the adoption of hydrated, premade liquid, buffers and buffer concentrates can be a cost-, time- and resource-saving alternative.
Contact us to discuss different alternative buffer management strategies that can be applied as either a stand-alone solution or in combination to achieve workflow improvements, depending on the size of your operations and facility.
Featured Buffer Management Solutions
Flowmor™ Packaging System
A unique packaging system to maintain easy-to-handle, free-flowing hygroscopic salt.
J.T.Baker® Direct Dispense packaging system
A novel packaging platform for direct delivery of powdered raw materials into the process to streamline and enhance effectiveness in biomanufacturing workflows.
Hydrated buffers and buffer concentrates
A novel packaging platform for direct delivery of powdered raw materials into the process to streamline and enhance effectiveness in biomanufacturing workflows.
Avantor® Inline Dilution Buffer System
Designed to streamline buffer delivery in downstream applications.
Improving mAb manufacturing productivity
It is common for biologics manufacturing processes to require hundreds of raw materials, ranging from media and media supplements, buffers, and salts to other process chemicals.
Webinar: Process debottlenecking in buffer and media prep using enhanced raw material release/delivery strategies
Innovative new technologies like single use powder packaging and in-line dilution can help reduce facility footprint, labor hours and overall cost-of-goods